Distinct CpG oligonucleotide sequences activate human γ δ T cells via interferon-α/-β
نویسندگان
چکیده
منابع مشابه
α β and γ δ T cells can share a late common precursor
Background: The subdivision of T cells into o13 and y8 subtypes is conserved throughout vertebrate development. The respective ap and y8 T-cell receptors (TCRs) are encoded by somatically rearranged genes. There has been broad speculation as to whether an individual thymocyte can become either a y T cell or an ao1 T cell as a result of stochastic gene rearrangement processes, or whether the two...
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متن کاملδ‐cells and β‐cells are electrically coupled and regulate α‐cell activity via somatostatin
KEY POINTS We used a mouse expressing a light-sensitive ion channel in β-cells to understand how α-cell activity is regulated by β-cells. Light activation of β-cells triggered a suppression of α-cell activity via gap junction-dependent activation of δ-cells. Mathematical modelling of human islets suggests that 23% of the inhibitory effect of glucose on glucagon secretion is mediated by β-cells ...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2001
ISSN: 0014-2980,1521-4141
DOI: 10.1002/1521-4141(200112)31:12<3525::aid-immu3525>3.0.co;2-5